TrumpRx launches with discounts on 40 drugs: 5 takeaways
The White House launched TrumpRx.gov Feb. 5, a federal direct-to-consumer platform offering discounts on 40 high-cost prescription drugs.
The site was first announced in September when the administration began negotiating most-favored-nation pricing agreements requiring drugmakers to match U.S. prices to the lowest paid in other developed countries. As of February, 16 of the 17 largest pharmaceutical manufacturers had signed on to the framework.
The launch of TrumpRx is a key part of President Donald Trump’s 2026 healthcare proposal released Jan. 15, which calls on Congress to codify the most-favored-nation pricing model and expand access to direct-pay drug discounts. The platform is designed to reduce out-of-pocket costs for patients by bypassing traditional insurance and applying manufacturer-set cash prices directly.
Those discounts are already reflected in price reductions for many of the country’s highest-expenditure drugs. For example, Novo Nordisk’s oral Wegovy pill entered the U.S. market in January at $299 per month through a manufacturer-run self-pay program. On TrumpRx.gov, the same product is now listed at prices starting as low as $149, depending on dosage. Similar discounts apply to injectable GLP-1 therapies, insulin, fertility treatments and other branded drugs included in the initial rollout.
Five takeaways:
1. The site launched with 40 of the nation’s highest-cost brand-name drugs.
TrumpRx.gov offers direct access to manufacturer discounts for 40 medications widely prescribed for chronic, high-expenditure conditions. The administration said the platform focuses on drugs with the greatest out-of-pocket burden for patients and the highest annual spending across payers. Prices reflect “most-favored-nation” benchmarks — the lowest prices paid by other developed countries.
Depending on the manufacturer, patients can access these prices in one of two ways:
• Printable or digital TrumpRx coupons redeemable at retail pharmacies
• Manufacturer-integrated tools, such as ordering portals or fulfillment links built into TrumpRx.gov
TrumpRx.gov does not process payments but serves as a connector to manufacturer-run programs. Eligibility requires a valid prescription, and participation varies by drug.
2. Five manufacturers are participating under MFN pricing agreements.
The initial launch includes discounted products from AstraZeneca, Eli Lilly, EMD Serono, Novo Nordisk and Pfizer — the first drugmakers to sign voluntary MFN pricing deals with the Trump administration. Additional manufacturers that have signed agreements will have products added to the platform over time.
3. Prices for GLP-1 drugs used to treat diabetes and obesity dropped by up to 85%.
These therapies are among the highest-spend medications in the U.S. Ozempic and injectable Wegovy dropped from $1,028 and $1,349 per month to average prices around $350, with some doses as low as $199. The newly approved Wegovy pill, which launched in January at $299 per month, is now available on the site starting at $149. Eli Lilly’s Zepbound was reduced from $1,088 per month to as low as $299. Pricing varies by dosage.
4. The platform includes fertility medications with significant out-of-pocket savings.
The administration said many patients pay for fertility drugs entirely out of pocket and will now save more than $2,000 per treatment cycle, on average. Gonal-F is listed as low as $168 per pen. Cetrotide and Ovidrel — both commonly used in fertility protocols — are discounted from $316 and $251 to $22.50 and $84, respectively.
5. Additional treatments are available for respiratory, dermatologic and hormonal conditions.
Several other high-cost medications were included in the first wave of pricing deals:
- Bevespi Aerosphere for COPD: $458 to $51
- Airsupra for asthma: $504 to $201
- Eucrisa for atopic dermatitis: $792 to $158
- Duavee for hot flashes and osteoporosis: $202 to $30
- Insulin lispro: as low as $25 per month
These medications are used to manage long-term conditions and were among the branded products listed with the steepest price reductions.
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